If you’re considering melatonin supplements for sleep, it’s important to understand how they work: 1️⃣ It's a hormone: Treat it as such. Melatonin plays a crucial role in the sleep-wake cycle. Natural levels of melatonin in the blood are highest at night, so work with, not against, melatonin’s sleep-inducing signal. 2️⃣ Start small: Begin with a small dose of just 0.5 mg and check with your doctor first. 3️⃣ Use sparingly: Use melatonin supplements irregularly and sparingly if you’re experiencing insomnia or want to overcome jet lag.